Tirzepatide vs semaglutide: the cost difference
Same providers, both molecules, so the premium is measured like-for-like instead of across different fee structures.
As of August 31, 2026:
Semaglutide is the cheaper molecule: verified medians are $178 per month month-to-month against $299 for tirzepatide, and $2,078.50 against $2,886 on 12-month all-in cost. At the 20 providers publishing both, the median tirzepatide premium on their cheapest plans is $52 per month. Whether the premium is worth it is a clinical question for a prescriber, not a pricing one; this page only prices it.
| Provider | Tirzepatide /mo | Semaglutide /mo | Tirzepatide premium | Grades |
|---|---|---|---|---|
| Embody | $119month-to-month | $69month-to-month | $50 | D D |
| SnagRx | $119month-to-month | $69month-to-month | $50 | D D |
| Trimi | $12512-month plan | $9912-month plan | $26 | B B |
| NexLife | $13912-month plan | $11912-month plan | $20 | A A |
| Sunlight | $157month-to-month | $88month-to-month | $69 | B B |
| TMates | $16712-month plan | $15812-month plan | $9 | D D |
| Fifty 410 | $1663-month plan | $199month-to-month | $-33 | D A |
| Gala Health | $17912-month plan | $179month-to-month | $0 | D D |
| Ozari Health | $1993-month plan | $1453-month plan | $54 | B B |
| Care Bare Rx | $199month-to-month | $199month-to-month | $0 | D D |
| Ivím Health | $183.336-month plan | $1006-month plan | $83.33 | A A |
| Mochi Health | $199month-to-month | $99month-to-month | $100 | A A |
| Orderly Meds | $299month-to-month | $149month-to-month | $150 | A A |
| Enhance MD | $280month-to-month | $212month-to-month | $68 | D D |
| Noom Med | $2993-month plan | $2493-month plan | $50 | A A |
| Luvo Health | $29112-month plan | $19412-month plan | $97 | D D |
| Sprout Health | $349month-to-month | $299month-to-month | $50 | D D |
| Zappy Health | $349month-to-month | $249month-to-month | $100 | A A |
| Remedy Meds | $399month-to-month | $299month-to-month | $100 | A A |
| Direct Meds | $399month-to-month | $297month-to-month | $102 | D D |
Grades: A = price and terms verified on the provider’s page; B = price verified, some terms unpublished; C = introductory price only; D = third-party report, not verified by us; U = no public price. Grade D rows are shown for completeness and are never counted in verified statistics. Full definitions.
Questions this page answers
How much more does tirzepatide cost than semaglutide?
Semaglutide is the cheaper molecule: verified medians are $178 per month month-to-month against $299 for tirzepatide, and $2,078.50 against $2,886 on 12-month all-in cost. At the 20 providers publishing both, the median tirzepatide premium on their cheapest plans is $52 per month. Whether the premium is worth it is a clinical question for a prescriber, not a pricing one; this page only prices it.